Most progesterone creams contain micronized hormone (ground to micron-size particles). In most of those preparations only small portion of progesterone is dissolved, the rest is suspended as micron-size particles. Those particles cannot be absorbed by the skin and remain on its surface. Progesterone is wasted as a result, requiring application of larger amounts to make up for the loss.
Unabsorbed progesterone is transferred onto clothing, objects and people we touch. Unabsorbed constituents of dried cream contaminate our environment: they become part of the dust we breathe in.

An average brand of progesterone cream can be in a certain way compared to coffee with added sugar that hasn't been stirred. Even though the amount of sugar is right, coffee isn't sweet because sugar remains undissolved.

In making ClearPatch lotions we go a step further. We start with micronized USP grade progesterone (estriol, DHEA) and make them fully dissolved. Only in this form the hormones can be absorbed by skin and are 100% bioavailable.

The efficiency of ClearPatch lotions allows to maintain physiological levels of progesterone using doses smaller in comparison with creams.