Most progesterone creams contain micronized hormone (ground to micron-size particles). In most of those preparations only small portion of progesterone is dissolved, the rest is suspended as micron-size particles. Those particles cannot be absorbed by the skin and remain on its surface. Progesterone is wasted as a result, requiring application of larger amounts to make up for the loss.
Unabsorbed progesterone is transferred onto clothing, objects and people we touch. Unabsorbed constituents of dried cream contaminate our environment: they become part of the dust we breathe in.

An average brand of progesterone cream can be in a certain way compared to coffee with added sugar that hasn't been stirred. Even though the amount of sugar is right, coffee isn't sweet because sugar remains undissolved.

In making ClearPatch^® lotions we go a step further. We start with micronized USP grade progesterone (estriol, DHEA) and make them fully dissolved. Only in this form the hormones can be absorbed by skin and are 100% bioavailable.

The efficiency of ClearPatch lotions allows to maintain physiological levels of progesterone using doses smaller in comparison with creams.